Mexican Casserole

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A quick and cheesy Mexican casserole made with pantry ingredients and shredded cheddar cheese. Best of all it’s done in 30-minutes or less!

This is one of the recipes Kim’s grandmother used to make every time we visited. It’s a cheesy, filling, comfort dish.

Much like our creamy chicken noodle casserole, Mexican Street Corn Pasta Salad and Green Chile Chicken Casserole, it uses a lot of pantry staples, like canned cream of chicken soup.

Like I said before, the best part is that’s done in 30-minutes or less.

Mexican casserole in a cast iron skillet.

As far as side dishes are concerned, I recommend serving it alongside our Mexican rice; another recipe from kid’s childhood.

When paired together, you have a tasty Tex-Mex meal that the whole family will love.

Shall we get started?

A close-up of the baked casserole in a skillet.

How to make one-skillet Mexican casserole?

First, start by preheating your oven to 350 degrees F. and placing a large skillet over medium heat.

Brown the ground beef in the skillet and drain away the extra grease. Remove the skillet from the heat.

Ground beef cooking in a cast iron skillet.

Next, open the cans of cream of chicken and mushroom soup, enchilada sauce, green chiles, and evaporated milk.

Afterward, pour all the ingredients into the skillet with beef and stir everything together.

Soup and other ingredients added to the beef.

Including the tortilla chips. Break them up a little before tossing them into the Mexican casserole.

Then, sprinkle the cheese on top of the casserole and place it into the oven to bake.

Shredded cheese added to the skillet.

Last, let the dish bake for about 25-minutes. Everything should bubbling with melted cheese!

Remove it from the oven and serve hot. That’s it, your Tex-Mex casserole is done!

Leftovers can be stored in a sealed container, in your fridge, for up to 3-days. Kim and I hope you enjoy it and wish you all the best 🙂

The casserole has baked and is ready to serve.

Recipe Tips:

  • If you use a cast iron skillet (oven-safe) like ours, then you only need one pan to create the Mexican casserole. However, if you don’t have one, cook the ground beef in a pan, drain the grease, and transfer the meat to a greased 9×13-inch baking dish. After that, follow the rest of the recipe as it is written.
  • For our casserole, we used 90/10 ground beef. But, you can use any fat ratio you want. Just keep in mind that you’ll need to drain away the leftover grease before prepping the casserole to bake.
  • Kim’s grandmother used to crumble tortilla chips and sprinkle them over the casserole for a nice crunchy topping.
Cheesy tex-mex casserole in a pan.

Other Casseroles to Try:

An aerial view of the mexican casserole in a skillet.

Mexican Casserole

4.6 from 5 votes
Print Pin
Author: Kimberly
Prep Time: 5 minutes
Cook Time: 25 minutes
Total Time: 30 minutes
Servings: 8 Servings


  • 1 ½ pounds ground beef, we used 90/10
  • 8 ounces tortilla chips, broken into small pieces
  • 10 ½ ounces cream of mushroom soup, 1 can
  • 10 ½ ounces cream of chicken soup, 1 can
  • 10 ounces enchilada sauce, 1 can
  • 4 ounces green chiles, 1 can, undrained
  • 5 ounces evaporated milk, 1 can
  • 1 ½ cups sharp cheddar cheese, shredded


  • Preheat the oven to 350°F.
  • In a large skillet (we used a 13-inch oven safe skillet), cook the ground beef, and drain the grease.
    1 ½ pounds ground beef
  • Return the ground beef to the skillet, and add the remaining ingredients except the cheese. Stir to combine. Top with shredded cheese. Bake for 20 minutes, and serve hot.
    8 ounces tortilla chips
    10 ½ ounces cream of mushroom soup
    10 ½ ounces cream of chicken soup
    10 ounces enchilada sauce
    4 ounces green chiles
    5 ounces evaporated milk
    1 ½ cups sharp cheddar cheese
  • Store any leftovers in the refrigerator for up to 3 days.

Suggested Equipment


The calories listed are an approximation based on the ingredients in the recipe card and a serving size of about 1-cup of the Mexican casserole. Actual calories will vary.


Serving: 1cup | Calories: 452kcal | Carbohydrates: 33g | Protein: 29g | Fat: 22g | Saturated Fat: 10g | Polyunsaturated Fat: 2g | Monounsaturated Fat: 7g | Trans Fat: 1g | Cholesterol: 86mg | Sodium: 1212mg | Potassium: 485mg | Fiber: 3g | Sugar: 5g | Vitamin A: 588IU | Vitamin C: 3mg | Calcium: 258mg | Iron: 3mg

Nutrition Disclaimer

Kim and John Vargo of Berly’s Kitchen and its affiliates are not dieticians or nutritionists. Any nutritional information shared is an estimate. If preferred, use your favorite online nutrition calculator to double check the amounts. Calories and other nutritional values can vary based on brand and serving size.

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4.60 from 5 votes (5 ratings without comment)

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